Some studies will examine the incidence of a combined endpoint, which can merge a variety of outcomes into one group. For example, the heart attack study above may report the incidence of the combined endpoint of chest pain, myocardial infarction, or death. An example of a cancer study powered for a combined endpoint is disease-free survival (DFS); trial participants experiencing either death or discovery of any recurrence would constitute the endpoint.
Regarding humane endpoints, a combined endpoint may constitute a threshold where there is enough cumulative degree of disease, symptoms, signs or laboratory abnormalities to motivate an intervention.
Read more about this topic: Clinical Endpoint
Famous quotes containing the word combined:
“I am absurdly fearful about this voyage. Various little omens have combined to give me a dark feeling.... Perhaps we shall live to laugh at these. But in case of mishap I should perish with my husband and child, perhaps to be transferred to some happier state.”
—Margaret Fuller (1810–1850)