Cletus or Cleatus may refer to:
- Pope Anacletus
- Antipope Anacletus II
People or characters with the given name Cletus:
- Cletus Spuckler, a fictional character in The Simpsons
- Cletus Hogg, a deputy in the TV show The Dukes of Hazzard
- Cletus Kasady, a Marvel Comics supervillain also known as Carnage
- Cletus Andersson (1893–1971), Swedish water polo player
- Cletus Clark (born 1962), retired male hurdler from the United States
- Cletus Dunn (born 1948), former civil servant and Canadian politician
- Cletus Ibeto (born 1952), Nigerian businessman
- Cletus Wotorson (born 1937), Liberian politician and geologist
- Cleatus the Fox Sports Robot, the robotic mascot of NFL on Fox
- Cleatus, a minor character on Good Times