CLE may refer to:

  • Current-limiting element, a fuse designed to limit current in power systems
  • Central Landing Establishment
  • Chemical Langevin equation, a stochastic ordinary differential equation
  • The stock symbol for Claire's, a retailer of accessories and jewelry to girls and young women
  • Cleveland, Ohio
    • IATA airport code for Cleveland Hopkins International Airport
    • The Cleveland Weather Forecast Office of the U.S. National Weather Service
    • The Cleveland Indians, Browns, or Cavaliers
  • Continuing legal education, the professional education of lawyers that takes place after their initial admission to the bar
  • Continuous lumbar epidural infusion, a common type of epidural anesthesia
  • Leukoencephalopathy with vanishing white matter
  • Chu–Liu–Edmonds algorithm, an algorithm for finding optimal branchings in graph theory