Claviceps Purpurea - Effects

Effects

The disease cycle of the ergot fungus was first described in 1853, but the connection with ergot and epidemics among people and animals was reported already in a scientific text in 1676. The ergot sclerotium contains high concentrations (up to 2% of dry mass) of the alkaloid ergotamine, a complex molecule consisting of a tripeptide-derived cyclol-lactam ring connected via amide linkage to a lysergic acid (ergoline) moiety, and other alkaloids of the ergoline group that are biosynthesized by the fungus. Ergot alkaloids have a wide range of biological activities including effects on circulation and neurotransmission.

Ergotism is the name for sometimes severe pathological syndromes affecting humans or animals that have ingested ergot alkaloid-containing plant material, such as ergot-contaminated grains. Monks of the order of St. Anthony the Great specialized in treating ergotism victims with balms containing tranquilizing and circulation-stimulating plant extracts; they were also skilled in amputations. The common name for ergotism is "St. Anthony's Fire", in reference to monks who cared for victims as well as symptoms, such as severe burning sensations in the limbs. These are caused by effects of ergot alkaloids on the vascular system due to vasoconstriction of blood vessels, sometimes leading to gangrene and loss of limbs due to severely restricted blood circulation.

The neurotropic activities of the ergot alkaloids may also cause hallucinations and attendant irrational behaviour, convulsions, and even death. Other symptoms include strong uterine contractions, nausea, seizures, and unconsciousness. Since the Middle Ages, controlled doses of ergot were used to induce abortions and to stop maternal bleeding after childbirth. Ergot alkaloids are also used in products such as Cafergot (containing caffeine and ergotamine or ergoline) to treat migraine headaches. Ergot extract is no longer used as a pharmaceutical preparation.

Ergot contains no lysergic acid diethylamide (LSD) but rather ergotamine, which is used to synthesize lysergic acid, an analog of and precursor for synthesis of LSD. Moreover, ergot sclerotia naturally contain some amounts of lysergic acid.