Steps Leading To C3-convertase
At first, a conformational change in C1r occurs, followed by proteolytic activation, which results in the cleavage of all four polypeptide chains of C1r2s2.
The two activated C1s subunits are then able to catalyse the assembly of the C3-convertase, C4bC2a, which has been formed from C2 and C4.
Read more about this topic: Classical Complement Pathway
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