CLA may refer to:
- Cleaning, Lubrication & Adjustment; a type of maintenance service / repair work on camera bodies and photographic lenses
- Canadian Lacrosse Association
- Canadian Library Association
- Caprivi Liberation Army
- Carry Look-Ahead Adder
- Caseous lymphadenitis, disease of sheep and goats affecting the lymphoid organs
- Causal layered analysis
- Certified Legal Assistant
- Chris Lord-Alge
- Cigarette Lighter Adapter
- Civil Liberties Association, especially:
- Canadian Civil Liberties Association
- Clandon railway station, Surrey, England; station code CLA
- Claremont (Amtrak station), New Hampshire, United States; Amtrak station code CLA
- Classroom/Laboratory/Administration building (CLA building) a 183,000-square-foot (17,000 m2) building in the Cal Poly Pomona campus
- Clutterers Anonymous
- College of Liberal Arts (disambiguation), multiple institutions
- Collegiate Learning Assessment, a standardized test of higher education used in the US.
- Command-line argument
- Communist League of America, a Trotskyist political party that existed from 1928 to 1934
- Conjugated linoleic acid (a naturally occurring trans fat in the human diet; also a dietary supplement)
- Contributor License Agreement
- Country Land and Business Association (formerly the Country Landowners' Association)
- Cuban Liberator Army
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