Mode of Action
Cis-regulatory modules can regulate their target genes over large distances, several models have been proposed to describe the way that these modules may communicate with their target gene promoter. DNA Scanning Model: In this model the transcription factor and cofactor complex form at the cis-regulatory module and then continues to move along the DNA sequence until it finds the target gene promoter. Looping Model: In this model the transcription factor binds to the cis-regulatory module, which then causes the looping of the DNA sequence and allows for the interaction with the target gene promoter. Facilitated Tracking Model: This model combines parts of the two previous models. The transcription factor-cis-regulatory module complex causes the looping of the DNA sequence slowly towards the target promoter and forms a stable looped configuration.
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