Mode of Action
Cis-regulatory modules can regulate their target genes over large distances, several models have been proposed to describe the way that these modules may communicate with their target gene promoter. DNA Scanning Model: In this model the transcription factor and cofactor complex form at the cis-regulatory module and then continues to move along the DNA sequence until it finds the target gene promoter. Looping Model: In this model the transcription factor binds to the cis-regulatory module, which then causes the looping of the DNA sequence and allows for the interaction with the target gene promoter. Facilitated Tracking Model: This model combines parts of the two previous models. The transcription factor-cis-regulatory module complex causes the looping of the DNA sequence slowly towards the target promoter and forms a stable looped configuration.
Read more about this topic: Cis-regulatory Module
Famous quotes containing the words mode of, mode and/or action:
“Literature exists at the same time in the modes of error and truth; it both betrays and obeys its own mode of being.”
—Paul Deman (1919–1983)
“If Thought is capable of being classed with Electricity, or Will with chemical affinity, as a mode of motion, it seems necessary to fall at once under the second law of thermodynamics as one of the energies which most easily degrades itself, and, if not carefully guarded, returns bodily to the cheaper form called Heat. Of all possible theories, this is likely to prove the most fatal to Professors of History.”
—Henry Brooks Adams (1838–1918)
“A servant with this clause
Makes drudgery divine:
Who sweeps a room as for Thy laws
Makes that and th’ action fine.”
—George Herbert (1593–1633)