Mode of Action
Cis-regulatory modules can regulate their target genes over large distances, several models have been proposed to describe the way that these modules may communicate with their target gene promoter. DNA Scanning Model: In this model the transcription factor and cofactor complex form at the cis-regulatory module and then continues to move along the DNA sequence until it finds the target gene promoter. Looping Model: In this model the transcription factor binds to the cis-regulatory module, which then causes the looping of the DNA sequence and allows for the interaction with the target gene promoter. Facilitated Tracking Model: This model combines parts of the two previous models. The transcription factor-cis-regulatory module complex causes the looping of the DNA sequence slowly towards the target promoter and forms a stable looped configuration.
Read more about this topic: Cis-regulatory Module
Famous quotes containing the words mode of, mode and/or action:
“Almost any mode of observation will be successful at last, for what is most wanted is method.”
—Henry David Thoreau (1817–1862)
“The body sins once, and has done with its sin, for action is a mode of purification. Nothing remains then but the recollection of a pleasure, or the luxury of a regret.”
—Oscar Wilde (1854–1900)
“The grand principles of virtue and honor, however they may be distorted by arbitrary codes, are the same the world over: and where these principles are concerned, the right or wrong of any action appears the same to the uncultivated as to the enlightened mind.”
—Herman Melville (1819–1891)