Mode of Action
Cis-regulatory modules can regulate their target genes over large distances, several models have been proposed to describe the way that these modules may communicate with their target gene promoter. DNA Scanning Model: In this model the transcription factor and cofactor complex form at the cis-regulatory module and then continues to move along the DNA sequence until it finds the target gene promoter. Looping Model: In this model the transcription factor binds to the cis-regulatory module, which then causes the looping of the DNA sequence and allows for the interaction with the target gene promoter. Facilitated Tracking Model: This model combines parts of the two previous models. The transcription factor-cis-regulatory module complex causes the looping of the DNA sequence slowly towards the target promoter and forms a stable looped configuration.
Read more about this topic: Cis-regulatory Module
Famous quotes containing the words mode of, mode and/or action:
“Curiously enough, it seems to be only in describing a mode of language which does not mean what it says that one can actually say what one means.”
—Paul Deman (1919–1983)
“That the mere matter of a poem, for instance—its subject, its given incidents or situation; that the mere matter of a picture—the actual circumstances of an event, the actual topography of a landscape—should be nothing without the form, the spirit of the handling, that this form, this mode of handling, should become an end in itself, should penetrate every part of the matter;Mthis is what all art constantly strives after, and achieves in different degrees.”
—Walter Pater (1839–1894)
“Power is action; the electoral principle is discussion. No political action is possible when discussion is permanently established.”
—Honoré De Balzac (1799–1850)