ChIP-loop
This method is slightly different from the previous techniques in that the interaction formed between two chromosomal regions is mediated by a bound protein. Like in the 5C methodology, a single DNA site is often considered to interact with multiple other sites. After the cross-linking and digestion, ChIP is performed to pull down the protein bound to the site of interest. Normal 3C procedures are conducted after this step.
Read more about this topic: Chromosome Conformation Capture