Awards and Nominations
| Year | Association | Category | Nominated work | Result |
|---|---|---|---|---|
| 1988 | Young Artist Awards | Best Young Actress in a Comedy Series | Married... with Children | Nominated |
| 1989 | Young Artist Awards | Best Young Actress in a Comedy Series | Married... with Children | Won |
| 1992 | MTV Movie Awards | Most Desirable Female | Don't Tell Mom the Babysitter's Dead | Nominated |
| 1992 | Young Artist Awards | Outstanding Young Ensemble Cast in a Motion Picture | Don't Tell Mom the Babysitter's Dead | Nominated |
| 1999 | Golden Globe Awards | Best Actress – Television Series Musical or Comedy | Jesse | Nominated |
| 1999 | People's Choice Awards | Favorite Female Performer in a New Television Series | Jesse | Won |
| 1999 | TV Guide Award | Favorite Star in a New Series | Jesse | Won |
| 2003 | Teen Choice Awards | Choice Movie Villain | View from the Top | Nominated |
| 2003 | Primetime Emmy Awards | Outstanding Guest Actress in a Comedy Series | Friends | Won |
| 2004 | Primetime Emmy Awards | Outstanding Guest Actress in a Comedy Series | Friends | Nominated |
| 2005 | Tony Awards | Tony Award for Best Actress in a Musical | Sweet Charity | Nominated |
| 2008 | Golden Globe Awards | Best Actress – Television Series Musical or Comedy | Samantha Who? | Nominated |
| 2008 | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Comedy Series | Samantha Who? | Nominated |
| 2008 | Teen Choice Awards | Choice TV Actress: Comedy | Samantha Who? | Nominated |
| 2008 | Television Critics Association Awards | Individual Achievement in Comedy | Samantha Who? | Nominated |
| 2008 | Prism Awards | Best Performance in a Comedy Series | Samantha Who? | Nominated |
| 2008 | Satellite Awards | Best Actress – Television Series Musical or Comedy | Samantha Who? | Nominated |
| 2008 | Primetime Emmy Awards | Outstanding Lead Actress in a Comedy Series | Samantha Who? | Nominated |
| 2009 | Golden Globe Awards | Best Actress – Television Series Musical or Comedy | Samantha Who? | Nominated |
| 2009 | Primetime Emmy Awards | Outstanding Lead Actress in a Comedy Series | Samantha Who? | Nominated |
| 2009 | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Comedy Series | Samantha Who? | Nominated |
| 2009 | TV Land Award | Innovator Award | Married... with Children | Won |
| 2009 | People's Choice Awards | Favorite Female TV Star | Samantha Who? | Won |
| 2010 | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Comedy Series | Samantha Who? | Nominated |
| 2012 | Satellite Awards | Best Actress – Television Series Musical or Comedy | Up All Night | Nominated |
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