Function
The protein encoded by this gene, CHK2 a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest.
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage.
Read more about this topic: CHEK2
Famous quotes containing the word function:
“The uses of travel are occasional, and short; but the best fruit it finds, when it finds it, is conversation; and this is a main function of life.”
—Ralph Waldo Emerson (1803–1882)
“The function of literature, through all its mutations, has been to make us aware of the particularity of selves, and the high authority of the self in its quarrel with its society and its culture. Literature is in that sense subversive.”
—Lionel Trilling (1905–1975)
“For me being a poet is a job rather than an activity. I feel I have a function in society, neither more nor less meaningful than any other simple job. I feel it is part of my work to make poetry more accessible to people who have had their rights withdrawn from them.”
—Jeni Couzyn (b. 1942)