Proposal On The Use of Drosophila
He is credited with first breeding Drosophila in quantity while he was at Harvard. Thomas Hunt Morgan's Nobel Prize biography says that C.W. Woodworth suggested to William E. Castle that Drosophila might be used for genetical work. Castle and his associates used it for their work on the effects of inbreeding, and through them F. E. Lutz became interested in it and the latter introduced it to Morgan, who was looking for less expensive material that could be bred in the very limited space at his command. Shortly after he commenced work with this new material (1909), a number of striking mutants turned up. Morgan's subsequent studies on this phenomenon ultimately enabled the determination of the precise behaviour and exact localization of genes.
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