Chargaff's rules state that DNA from any cell of all organisms should have a 1:1 ratio (base Pair Rule) of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine. This pattern is found in both strands of the DNA. They were discovered by Austrian chemist Erwin Chargaff.
Read more about Chargaff's Rules: Chargaff Parity Rule 1, Chargaff Parity Rule 2, Research, Relative Proportions (%) of Bases in DNA
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“Those rules of old discovered, not devised,
Are Nature sill, but Nature methodized;
Nature, like liberty, is but restrained
By the same laws which first herself ordained.”
—Alexander Pope (1688–1744)