Chambliss may refer to:
- John R. Chambliss (1833–1864), American soldier
- John R. Chambliss, Sr. (1809–1875), American politician
- Chris Chambliss (born 1948), American baseball player
- Saxby Chambliss (born 1948), American politician, Senior Senator from Georgia
- Kirby Chambliss (born 1959), American flier
- Richard Wayne Chambliss, Jr. (born 1973), American poet
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