Cerna may refer to:
- Croatia
- Cerna, Croatia, a village in Vukovar-Syrmia County, Croatia
- Romania
- Cerna River (Danube), a river in Romania, tributary of the Danube
- Cerna River (Mureş), a river in Romania, tributary of the Mureş River
- Cerna River (Olt), a river in Romania, tributary of the Olt River
- Cerna, Tulcea, a commune in Tulcea County, Romania
- Cerna, Timiş, a village in Liebling Commune, Timiş County, Romania
- Cerna, Vâlcea, a village in Vaideeni Commune, Vâlcea County, Romania
- Czech Republic
- Černá, village in the Czech Republic
- Family name
- Ricardo Alfonso Cerna
- Molecular biology
- ceRNA, competing endogenous RNA, a function of microRNA