Cen or CEN may refer to:
- Cen, or sen, is the currency of the fictional nation of Amestris of the anime/manga Fullmetal Alchemist
- Cen, a rune of the Anglo-Saxon fuþorc; see Kaunan
As a three-letter acronym:
- Cambridge Evening News, former name for the Cambridge News
- Center for Electron Nanoscopy, an institute at the Technical University of Denmark (DTU)
- Certified Emergency Nurse
- Creative Environmental Networks
- European Committee for Standardization (Comité Européen de Normalisation)
- SCK•CEN: The Belgian nuclear research institute (Centre d'Étude de l'énergie Nucléaire)
As an abbreviation or code:
- Centaurus, the constellation
- California State Prison, Centinela
- Central Station (MTR), Hong Kong
- Centralia, Illinois (Amtrak station)
- Ciudad Obregón International Airport (IATA code: CEN)
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