Issue
She married on October 4, 1570 in Paris to Henri de Lorraine, Duke of Guise, by whom she had fourteen children:
- Charles, Duke of Guise (1571–1640), who succeeded him
- Henri (June 30, 1572, Paris – August 13, 1574)
- Catherine (November 3, 1573) (died at birth)
- Louis III, Cardinal of Guise (1575–1621), Archbishop of Reims
- Charles (January 1, 1576, Paris) (died at birth)
- Marie (June 1, 1577–1582)
- Claude, Duke of Chevreuse (1578–1657) married Marie de Rohan, daughter of Hercule de Rohan, duc de Montbazon
- Catherine (b. May 29, 1579), d. young
- Christine (January 21, 1580) (died at birth)
- François (May 14, 1581 – September 29, 1582)
- Renée (1585 – June 13, 1626, Reims), Abbess of St. Pierre
- Jeanne (July 31, 1586 – October 8, 1638, Jouarre), Abbess of Jouarre
- Louise Marguerite, (1588 – April 30, 1631, Château d'Eu), married at the Château de Meudon on July 24, 1605 François, Prince of Conti
- François Alexandre (February 7, 1589 – June 1, 1614, Château des Baux), a Knight of the Order of Malta
Read more about this topic: Catherine Of Cleves
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—William Shakespeare (15641616)