Carbodiimide - DIC

DIC (acronym for N,N'-diisopropylcarbodiimide) was developed as an alternative to DCC. DIC is identical to DCC in nearly every way except:

1. As a liquid, DIC is easier to handle than DCC (which is a waxy solid).
2. The product, N,N'-diisopropylurea, is soluble in organic solvents and is easily removed by extraction. Hence, DIC is more often used in solid-phase synthesis.
3. DIC is far less likely than DCC to cause an allergic reaction.