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- Ralph Sazio – builder, 1988 (Hamilton Tiger-Cats as player 1950–53, head coach 1963–67, general manager 1968–75, 1980, president 1973–77, vice-president of football operations 1978–80; Toronto Argonauts as president 1981–90).
- Tom Scott – player (SB), 1998 (Winnipeg Blue Bombers 1974–77; Edmonton Eskimos 1978–83; Calgary Stampeders 1984).
- Vince Scott – player (DG), 1982 (Hamilton Wildcats 1949; Hamilton Tiger-Cats 1950, 1952–62).*
- Dick Shatto – player (FB/HB/SB/F), 1975 (Toronto Argonauts 1954–65).
- Frank "Shag" Shaughnessy – builder, 1963 (McGill University as coach 1912–28).*
- Tom Shepherd – builder, 2008 (Saskatchewan Roughriders as president 1966–present).*
- Hap Shouldice – builder, 1977 (mostly for contributions to league rules and officiating including the CFL's first director of officiating in 1972).*
- Ben Simpson – player (HB/K), 1963 (Queen's University 1899–1903; Hamilton Tigers 1904–10).*
- Bob Simpson – player (FW/RB/DB), 1976 (Windsor Rockets 1949; Ottawa Rough Riders 1950–62).
- Jimmie Simpson – builder, 1985 (Hamilton Tigers as player 1928–38; Hamilton Flying Wildcats as player 1943–44; Hamilton Tiger-Cats as trainer 1953–74; also for officiating 1945–56).*
- Karl Slocomb – builder, 1989 (Winnipeg Blue Bombers as executive 1940s–1950s, president 1953; later as president of WIFU 1956 and CRU 1960).*
- Victor Spencer – builder, 2006 (Hamilton Tigers as player BC Lions as club organizer, director, and executive in 1950s, serving other roles since then).
- David Sprague – player (RB/DT), 1963 (Hamilton Tigers 1930–32; Ottawa Rough Riders 1933–40).*
- Harry Spring – builder, 1976 (Meraloma Club (BCRFU) as president 1937; BC Lions as treasurer 1955–56, vice-president 1957, and president 1958–59).*
- Milt Stegall – player (SB), 2012 (Winnipeg Blue Bombers 1995–2008).
- Art Stevenson – player (RB/QB/K), 1969 (Winnipeg Blue Bombers 1937–41).
- Ron Stewart – player (RB), 1977 (Queen's University 1953–57; Ottawa Rough Riders 1958–70).
- Bummer Stirling – player (K/RB), 1966 (Sarnia Imperials 1929–38).*
- Annis Stukus – builder, 1974 (Toronto Argonauts as player 1935–41; Toronto Oakwood Indians as player/coach 1942; Toronto Balmy Beach Beachers as player 1943; HMCS York Navy Bulldogs as player 1944; Toronto Indians as player 1945–46; Edmonton Eskimos as player 1949–50, coach/general manager 1949–51; BC Lions as coach/general manager 1954–55).*
- Don Sutherin – player (DB/K), 1992 (Hamilton Tiger-Cats 1958, 1960–66; Ottawa Rough Riders 1967–69; Toronto Argonauts 1970).
- Bill Symons – player (HB), 1997 (BC Lions 1966; Toronto Argonauts 1967–73).
Read more about this topic: Canadian Football Hall Of Fame