Cadmium Compounds - Safety

Safety

The most dangerous form of occupational exposure to cadmium is inhalation of fine dust and fumes, or ingestion of highly soluble cadmium compounds. Inhalation of cadmium-containing fumes can result initially in metal fume fever but may progress to chemical pneumonitis, pulmonary edema, and death.

Cadmium is also an environmental hazard. Human exposures to environmental cadmium are primarily the result of fossil fuel combustion, phosphate fertilizers, natural sources, iron and steel production, cement production and related activities, nonferrous metals production, and municipal solid waste incineration. Bread, root crops, and vegetables also contribute to the cadmium in modern populations. There have been a few instances of general population toxicity as the result of long-term exposure to cadmium in contaminated food and water, and research is ongoing regarding the estrogen mimicry that may induce breast cancer. In the decades leading up to World War II, Japanese mining operations contaminated the Jinzū River with cadmium and traces of other toxic metals. As a consequence, cadmium accumulated in the rice crops growing along the riverbanks downstream of the mines. Some members of the local agricultural communities consuming the contaminated rice developed itai-itai disease and renal abnormalities, including proteinuria and glucosuria.

The victims of this poisoning were almost exclusively post-menopausal women with low iron and other mineral body stores. Similar general population cadmium exposures in other parts of the world have not resulted in the same health problems because the populations maintained sufficient iron and other mineral levels. Thus, while cadmium is a major factor in the itai-itai disease in Japan, most researchers have concluded that it was one of several factors. Cadmium is one of six substances banned by the European Union's Restriction on Hazardous Substances (RoHS) directive, which bans certain hazardous substances in electrical and electronic equipment but allows for certain exemptions and exclusions from the scope of the law.

Although some studies linked exposure to cadmium with lung and prostate cancer, there is still a substantial controversy about the carcinogenicity of cadmium. More recent studies suggest that arsenic rather than cadmium may lead to the increased lung cancer mortality rates. Furthermore, most data regarding the carcinogenicity of cadmium rely on research confounded by the presence of other carcinogenic substances.

Tobacco smoking is the most important single source of cadmium exposure in the general population. It has been estimated that about 10% of the cadmium content of a cigarette is inhaled through smoking. The absorption of cadmium from the lungs is much more effective than that from the gut, and as much as 50% of the cadmium inhaled via cigarette smoke may be absorbed.

On average, smokers have 4–5 times higher blood cadmium concentrations and 2–3 times higher kidney cadmium concentrations than non-smokers. Despite the high cadmium content in cigarette smoke, there seems to be little exposure to cadmium from passive smoking. No significant effect on blood cadmium concentrations has been detected in children exposed to environmental tobacco smoke.

Cadmium exposure is a risk factor associated with early atherosclerosis and hypertension, which can both lead to cardiovascular disease.