Gene Expression and Genome Replication
Once inside a host cell cytoplasm, the genomic RNA’s are transcribed into mRNA’s by the associated RNA polymerase. From these transcripts, the host machinery is used for translation into viral proteins. The S segment is slightly different from the rest as it is ambisense, meaning genes run in both the positive and negative directions. To enable correct translation of the proteins, a second round of transcription has to occur.
To replicate the genome, transcription occurs to produce a replicative intermediate, which is then itself transcribed into new RNA genomes, with the aid of the RNA polymerases produced from the gene expression.
Read more about this topic: Bwamba Fever
Famous quotes containing the word expression:
“As a man has no right to kill one of his children if it is diseased or insane, so a man who has made the gradual and conscious expression of his personality in literature the aim of his life, has no right to suppress himself any carefully considered work which seemed good enough when it was written. Suppression, if it is deserved, will come rapidly enough from the same causes that suppress the unworthy members of a man’s family.”
—J.M. (John Millington)