Burnout or burn-out may refer to:
- Burnout (psychology), a psychological term for a syndrome characterized by long-term exhaustion and diminished interest, especially in one's career
- Occupational burnout, characterized by exhaustion, cynicism, and reduced professional efficacy within the workplace
- Burnout (vehicle), when a vehicle's tires are spun so they smoke
- "Burn Out" (song), a 1983 song by Sipho Mabuse
- "Burnout", a song by Green Day from their 1994 album Dookie
- Burnout (comics), a fictional Wildstorm character
- Burn Out (album), a 1998 album by Christian pop punk band Slick Shoes
- Burnout (series), a racing game series created by UK company Criterion Games, with a notable emphasis on dangerous driving and crashes
- Burnout (video game), the first game in the same series
- "Burn Out" (CSI), an episode from the seventh season of the television series CSI: Crime Scene Investigation
- Burn Out (G.I. Joe), a fictional character in the G.I. Joe universe, member of the Dreadnoks