Bruiser may refer to:
- Bruiser (band), an indie rock trio that features ex-Local H drummer Joe Daniels
- Bruiser (film), a motion picture from veteran director George A. Romero
- Bruiser (TV series), a BBC television series
- Bruiser (Pillow Pal), a Pillow Pal dog made by Ty, Inc.
- HMS Bruiser, one of two British Royal Navy warships
- The Bruisers, musical pioneers of the Punk/Oi! genre
- Bruiser Woods, Elle Woods' chihuahua
- Bruiser, the name of a large demonic enemy in the expansion pack to Doom 3, Resurrection of Evil
- Bruiser (Molly Hayes) of the Runaways comic, her teammate's chosen alias for her
- Judge and Bruiser, costumed mascots for the Baylor University Bears
- Bruiser, the third studio album by The Duke Spirit