Histogenesis
Nonmucinous BAC is thought to derive from a transformed cell in the distal airways and terminal respiratory units, and often shows features of Clara cell or Type II pneumocyte differentiation. Mucinous BAC, in contrast, probably derives from a transformed glandular cell in distal bronchioles.
Type-I cystic adenomatoid malformation (CAM) has recently been identified as a precursor lesion for the development of mucinous BAC, but these cases are rare.
Rarely, BAC may develop a rhabdoid morphology due to the development of dense perinuclear inclusions.
Read more about this topic: Bronchioloalveolar Carcinoma