Storyline
The plot of Bob and George involves various re-tellings of the plot from the Mega Man video games, interspersed with the characters interacting and sometimes battling villains of Anez's own creation. Time travel and inter-dimensional travel are common occurrences, with many of the characters hailing from dimensions (or times) other than that of the main continuity. This leads to a number of temporal paradoxes.
Story lines frequently involve breaking the fourth wall, with the strips' Author being a regular character. A running theme of the comic is that most, if not all, of the characters are fully aware that they are in a webcomic.
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