Blume may refer to:
- Blume Bl.502, a family of four-seat light aircraft designed in West Germany by Dr Walter Blume in the late 1950s
- Blume High School, a historic building in downtown Wapakoneta, Ohio, United States
- Blume in Love, a 1973 film written and directed by Paul Mazursky
- 18106 Blume, an Amor asteroid discovered on 4 July 2000
- Desert Blume, Alberta, a hamlet in Canada
- People
- Anna and Bernhard Blume, German artistic photographers
- Brian Blume (born 1950), a business partner of Gary Gygax in TSR, Inc., producers of the fantasy role-playing game, Dungeons & Dragons
- Carl Ludwig Blume (1789–1862), a German-Dutch botanist
- Clemens Blume (1862–1932), a Jesuit hymnologist
- Clint Blume (1898–1973), a Major League Baseball player
- Danny Blume (born 1960), an American music producer, musician and composer
- David Blume, an American permaculture teacher and entrepreneur
- Fred H. Blume (1875–1971), a Justice of the Wyoming Supreme Court
- Friedrich Blume (1893–1975), a German professor of musicology in Kiel University
- Georg Blume, a correspondent in Beijing, China of the German newspapers "Die Zeit" and "taz"
- Heinrich Blume, German politician
- Holger Blume (born 1973), a German sprinter
- Joaquín Blume (1933–1959), a Spanish gymnast
- John Blume (1909–2002), an American structural engineer
- Judy Blume (born 1938), an American author
- Lawrence E. Blume, an American professor of economics
- Lesley M. M. Blume, an author, journalist, columnist and cultural observer based in New York City
- Marc Blume (born 1973), a German sprinter
- Marco Blume, a German professional Magic: The Gathering player
- Markus Blume (born 1975), a German politician
- Peter Blume (1906–1992), an American painter and sculptor
- Ray Blume (born 1958), a retired American basketball player
- Ricardo Blume (born 1933), a Peruvian actor and theater director
- Robert Blume (1868–1937), an American sailor serving in the United States Navy during the Spanish–American War who received the Medal of Honor for his actions
- Veronica Blume (born 1977), a Spanish fashion model and actress
- Walter Blume (1896–1964), a German fighter ace of World War I and aircraft designer
- Werner Blume (1911–1942), a German Luftwaffe reconnaissance pilot and recipient of the Knight's Cross of the Iron Cross during World War II