Blaylock is a family name that may refer to:
- Cheryl Blaylock, puppeteer from 1989 to 1995 on Eureeka's Castle
- Chet Blaylock (1924–1996), politician
- James Blaylock (born 1950), fantasy author
- Jeannie Blaylock, news anchor
- Len E. Blaylock (born 1918), farmer, educator, small businessman and Republican politician
- Louis Blaylock (1849–1932), Dallas-based publisher, civil leader and mayor
- Mattie Blaylock (Celia Ann Blaylock) (1850–1888), romantic companion of Old West gambler and lawman Wyatt Earp
- Ronald E. Blaylock, investment banker, founder of Blaylock & Company
- Russell Blaylock, neurosurgeon, author, lecturer, and newsletter editor
- Selwyn G. Blaylock (1879–1945), president of Cominco mining company
In sports:
- Anthony Blaylock (born 1965), former NFL cornerback
- Bob Blaylock (born 1935), former MLB pitcher
- Derrick Blaylock (born 1979), former NFL running back
- Gary Blaylock (born 1931), former MLB pitcher
- Marv Blaylock (1929-1993), MLB first baseman
- Mookie Blaylock (born 1967), former NBA player
- Ron Blaylock, football coach of Emporia State University
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