Birtwistle may refer to:
- Adam Birtwistle (born 1959), British artist
- Alexander Birtwistle CBE (born 1948), retired British Army officer
- Gordon Birtwistle (born 1943), British Liberal Democrat politician
- Harrison Birtwistle CH (born 1934), British contemporary composer
- Sue Birtwistle, producer and writer of television drama
- Thomas Birtwistle (1833–1912), trade unionist and factory inspector