In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents. Activity is generally dosage-dependent. Further, it is common to have effects ranging from beneficial to adverse for one substance when going from low to high doses. Activity depends critically on fulfillment of the ADME criteria.
Whereas a material is considered bioactive if it has interaction with or effect on any cell tissue in the human body, pharmacological activity is usually taken to describe beneficial effects, i.e. the effects of drug candidates as well as a substance's toxicity.
In the study of biomineralisation, bioactivity is often meant as the formation of calcium phosphate deposits on the surface of objects placed in simulated body fluid, a buffer solution with ion content similar to blood.
Famous quotes containing the words biological and/or activity:
“Man’s biological weakness is the condition of human culture.”
—Erich Fromm (1900–1980)
“The superstition respecting power and office is going to the ground. The stream of human affairs flows its own way, and is very little affected by the activity of legislators. What great masses of men wish done, will be done; and they do not wish it for a freak, but because it is their state and natural end.”
—Ralph Waldo Emerson (1803–1882)