Big Sister may refer to:
- Big Sister (software), network monitoring software
- Big Sister (brothel), an online brothel in Prague
- "The Big Sister", an episode of Dexter's Laboratory
- "Big Sister," a song by Elvis Costello and the Attractions from Trust (Elvis Costello album)
- Big Sister's Island, one of the Sisters' Islands of Singapore
- Big Sisters part of the Big Brothers, Big Sisters program.
- Big Sister (radio) was a radio soap opera
- Big Sister, an enemy type in the game BioShock 2.
- Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
Famous quotes containing the words big and/or sister:
“Kicking the heart
with pain’s big boots running up and down
the intestines like a motorcycle racer.”
—Anne Sexton (1928–1974)
“One does not arise from such a book as Sister Carrie with a smirk of satisfaction; one leaves it infinitely touched.”
—H.L. (Henry Lewis)