Big Sister may refer to:
- Big Sister (software), network monitoring software
- Big Sister (brothel), an online brothel in Prague
- "The Big Sister", an episode of Dexter's Laboratory
- "Big Sister," a song by Elvis Costello and the Attractions from Trust (Elvis Costello album)
- Big Sister's Island, one of the Sisters' Islands of Singapore
- Big Sisters part of the Big Brothers, Big Sisters program.
- Big Sister (radio) was a radio soap opera
- Big Sister, an enemy type in the game BioShock 2.
- Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
Famous quotes containing the words big and/or sister:
“I hate cheap pictures. I hate pictures that make people look like they’re not worth much, just to prove a photographer’s point. I hate when they take a picture of someone pickin’ their nose or yawning. It’s so cheap. A lot of it is a big ego trip. You use people as props instead of as people.”
—Jill Freedman (b. 1939)
“It is natural not to care about a sister certainly not when she is four years older and grinds her teeth at night.”
—Gertrude Stein (1874–1946)