Big Sister may refer to:
- Big Sister (software), network monitoring software
- Big Sister (brothel), an online brothel in Prague
- "The Big Sister", an episode of Dexter's Laboratory
- "Big Sister," a song by Elvis Costello and the Attractions from Trust (Elvis Costello album)
- Big Sister's Island, one of the Sisters' Islands of Singapore
- Big Sisters part of the Big Brothers, Big Sisters program.
- Big Sister (radio) was a radio soap opera
- Big Sister, an enemy type in the game BioShock 2.
- Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
Famous quotes containing the words big and/or sister:
“We can glut ourselves with how-to-raise children information . . . strive to become more mature and aware but none of this will spare us from the . . . inevitability that some of the time we are going to fail our children. Because there is a big gap between knowing and doing. Because mature, aware people are imperfect too. Or because some current event in our life may so absorb or depress us that when our children need us we cannot come through.”
—Judith Viorst (20th century)
“Whoever does the will of God is my brother and sister and mother.”
—Bible: New Testament, Mark 3:35.
Jesus.