Big Sister may refer to:
- Big Sister (software), network monitoring software
- Big Sister (brothel), an online brothel in Prague
- "The Big Sister", an episode of Dexter's Laboratory
- "Big Sister," a song by Elvis Costello and the Attractions from Trust (Elvis Costello album)
- Big Sister's Island, one of the Sisters' Islands of Singapore
- Big Sisters part of the Big Brothers, Big Sisters program.
- Big Sister (radio) was a radio soap opera
- Big Sister, an enemy type in the game BioShock 2.
- Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
Famous quotes containing the words big and/or sister:
“Whale on the beach, you dinosaur,
what brought you smoothing into this dead harbor?
If you’d stayed inside you could have grown
as big as the Empire State.”
—Anne Sexton (1928–1974)
“of the satanic thistle that raises its horned symmetry
flowering above sister grass-daisies’ pink tiny
bloomlets angelic as lightbulbs—”
—Allen Ginsberg (b. 1926)