Big Sister may refer to:
- Big Sister (software), network monitoring software
- Big Sister (brothel), an online brothel in Prague
- "The Big Sister", an episode of Dexter's Laboratory
- "Big Sister," a song by Elvis Costello and the Attractions from Trust (Elvis Costello album)
- Big Sister's Island, one of the Sisters' Islands of Singapore
- Big Sisters part of the Big Brothers, Big Sisters program.
- Big Sister (radio) was a radio soap opera
- Big Sister, an enemy type in the game BioShock 2.
- Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
Famous quotes containing the words big and/or sister:
“In the mountains the shortest route is from peak to peak, but for that you must have long legs. Aphorisms should be peaks: and those to whom they are spoken should be big and tall of stature.”
—Friedrich Nietzsche (1844–1900)
“I should fear the infinite power and inflexible justice of the almighty mortal hardly as yet apotheosized, so wholly masculine, with no sister Juno, no Apollo, no Venus, nor Minerva, to intercede for me, thumoi phileousa te, kedomene te.”
—Henry David Thoreau (1817–1862)