The Battle of Pydna in 168 BC between Rome and the Macedonian Antigonid dynasty saw the further ascendancy of Rome in the Hellenic/Hellenistic world and the end of the Antigonid line of kings, whose power traced back to Alexander the Great.
Paul K. Davis writes that "Pydna marked the final destruction of Alexander’s empire and introduced Roman authority over the Near East."
Read more about Battle Of Pydna: Campaign, Battle, Aftermath
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