Barzini is a surname and may refer to:
- Benedetta Barzini (born 1943), Italian actress and model
- Luigi Barzini, Sr. (1874–1947), Italian journalist, war correspondent and writer
- Luigi Barzini, Jr. (1908–1984), Italian journalist
- Matteo Barzini (born 1981), Italian filmmaker and producer
- See also
- Barzini Family, fictional crime family in The Godfather
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