Backfire also may refer to:
- Back-fire, an explosion produced in a vehicle's engine
- "Backfire" (CSI: Miami), an episode of the TV show CSI:Miami
- Backfire!, an arcade game
- Backfire (album), by the Goa trance group Transwave
- Backfire (1950 film), featuring Virginia Mayo and Gordon Macrae
- Backfire (film), a 1987 movie starring Karen Allen
- Backfire! (film), a 1995 spoof movie starring Josh Mosby and Robert Mitchum
- Backfire, the NATO reporting name for the Russian Tupolev Tu-22M aircraft
- Operation Backfire (WWII), the launch of three A4 rockets in October 1945 near Cuxhaven
- Operation Backfire (FBI), an FBI operation against the radical environmental movement
- Controlled burn or backfire, a firefighting technique
- An alcoholic cocktail made of Bailey's Irish Cream, Kahlúa, and vodka in equal portions
- Version 10.03 of the OpenWrt firmware
- Backfire (Transformers), a fictional character
- Tupolev Tu-22M Nato reporting name Backfire, a USSR long range bomber