Type 1 (APMV-1)
Newcastle disease virus (NDV) strain Texas GB is a highly virulent neurotropic virus that is used as a standard vaccine challenge virus in the U.S. In this study, the complete genome sequence of strain Texas GB was determined and compared with the complete genome sequences of other NDV strains. The genome is 15,186 nucleotides (nt) long and consists of six genes in the order of 3'leader-N-P-M-F-HN-L-5'trailer. The genome contains a 55-nt leader sequence at the 3' end and a 114-nt trailer sequence at the 5' end. The intergenic sequences are 2, 1, 1, 31, and 47 nt between N/P, P/M, M/F, F/HN, and HN/L genes, respectively. The putative cleavage site of fusion protein showed amino acid sequence of R-R-Q-K-R downward arrow F in position 112 to 117, which corresponds to those of virulent NDV strains. The phylogenetic analysis showed that strain Texas GB is closely related to the neurovirulent mesogenic strain Beaudette C (BC) and to NDV viruses isolated in China and Egypt than to other strains of NDV.
Read more about this topic: Avian Paramyxovirus, Avian Paramyxovirus
Famous quotes containing the word type:
“It used to be said that you had to know what was happening in America because it gave us a glimpse of our future. Today, the rest of America, and after that Europe, had better heed what happens in California, for it already reveals the type of civilisation that is in store for all of us.”
—Alistair Cooke (b. 1908)