Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere. Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004). In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer.
Read more about Aurora B Kinase: History, Expression and Subcellular Localization, Regulation of Aurora B, Role in Chromosome Biorientation, Role in Chromosome Condensation and Chromosome Cohesion, Role in Cytokinesis, Role in The Spindle Assembly Checkpoint, Interactions, Role in Cancer
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