Career
After graduation in 1985, de Grey joined Sinclair Research Ltd as an AI/software engineer. In 1986, he co-founded Man-Made Minions Ltd to pursue the development of an automated formal program verifier. He met his wife, fruit-fly geneticist Adelaide Carpenter, at a graduate party in Cambridge, and through her was introduced to the science of anti-aging, when her boss needed someone who knew about computers and biology to take over the running of a database on fruit flies. From 1992 until 2006, he was in charge of software development at the university's Genetics Department for the FlyBase genetic database.
In 1999, his book The Mitochondrial Free Radical Theory of Aging was published, in which he writes that obviating damage to mitochondrial DNA might by itself extend lifespan significantly, though he said it was more likely that cumulative damage to mitochondria is a significant cause of senescence, but not the single dominant cause. On the basis of the book, the University of Cambridge awarded de Grey a PhD in 2000.
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