Pharmacogenetics
Several genetic polymorphisms have been found to be associated with a higher incidence of undesirable side-effects of atorvastatin. This phenomenon is suspected to be related to increased plasma levels of pharmacologically-active metabolites, such as atorvastatin lactone and p-hydroxyatorvastatin. Atorvastatin and its active metabolites may be monitored in potentially-susceptible patients using specific chromatographic techniques.
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