Cast (in Credits Order)
- Ronald Colman as Dr Martin Arrowsmith
- Helen Hayes as Leora Arrowsmith
- Richard Bennett as Gustav Sondelius
- A.E. Anson as Professor Max Gottlieb
- Clarence Brooks as Oliver Marchand
- Alec B. Francis as Twyford
- Claude King as Dr Tubbs
- Bert Roach as Bert Tozer
- Myrna Loy as Mrs Joyce Lanyon
- Russell Hopton as Terry Wickett
- David Landau as State Veterinarian
- Lumsden Hare as Sir Robert Fairland – Governor
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