Arene Substitution Patterns - Ipso, meso, and peri Substitution

Ipso, meso, and peri Substitution

  • ipso- substitution.

  • meso- substitution.

  • peri- substitution.

  • Ipso-substitution describes two substituents sharing the same ring position in an intermediate compound in an electrophilic aromatic substitution.
  • Meso-substitution refers to the substituents occupying a benzylic position. It is observed in compounds such as calixarenes and acridines.
  • Peri-substitution occurs in naphthalenes for substituents at the 1 and 8 positions.

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