Post Antibiotic Effect
The post antibiotic effect (PAE) is defined as persistent suppression of bacterial growth after a brief exposure (1 or 2 h) of bacteria to an antibiotic even in the absence of host defense mechanisms. Factors that affect the duration of the post antibiotic effect include duration of antibiotic exposure, bacterial species, culture medium and class of antibiotic. It has been suggested that an alteration of DNA function is possibly responsible for post antibiotic effect following the observation that most inhibitors of protein and nucleic acid synthesis (aminoglycosides, fluoroquinolones, tetracyclines, clindamycin, certain newer macrolides/ketolides, and rifampicin and rifabutin) induce long-term PAE against susceptible bacteria. Theoretically, the ability of an antibiotic to induce a PAE is an attractive property of an antibiotic since antibiotic concentrations could fall below the MIC for the bacterium yet retain their effectiveness in their ability to suppress the growth.
Read more about this topic: Antimicrobial Pharmacodynamics
Famous quotes containing the words post and/or effect:
“A demanding stranger arrived one morning in a small town and asked a boy on the sidewalk of the main street, “Boy, where’s the post office?”
“I don’t know.”
“Well, then, where might the drugstore be?”
“I don’t know.”
“How about a good cheap hotel?”
“I don’t know.”
“Say, boy, you don’t know much, do you?”
“No, sir, I sure don’t. But I ain’t lost.””
—William Harmon (b. 1938)
“The law before us, my lords, seems to be the effect of that practice of which it is intended likewise to be the cause, and to be dictated by the liquor of which it so effectually promotes the use; for surely it never before was conceived by any man entrusted with the administration of public affairs, to raise taxes by the destruction of the people.”
—Philip Dormer Stanhope, 4th Earl Chesterfield (1694–1773)