Pre-1881 (Odessa)
The first pogrom is sometimes considered to be the 1821 Odessa pogroms (in modern Ukraine) after the death of the Greek Orthodox patriarch Gregory V in Constantinople, in which 14 Jews were killed. The initiators of the 1821 pogroms were the local Greeks that used to have a substantial diaspora in the port cities of what was known as Novorossiya. Some sources consider the first pogrom to be the 1859 riots in Odessa.
Read more about this topic: Anti-Jewish Pogroms In The Russian Empire