Questions For Future Research
Despite the recent advances in the understanding of anthrax toxin, there are still several missing details in the action of anthrax toxin. These missing details leave questions about the molecular actions inside the cell.2 What role does EF play in hindering the immune system? Does it work with LF for its effect? How do the enzymes refold after translocation? Is there a chaperonin? Two proteins: KIF1C and the proteasome have shown a contribution to the effect of lethal toxin, but how do they contribute? Does LF target certain MAPKKs with a greater specificity? Does LF target other molecules too?
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