| Year |
Title |
Role |
Notes |
| 1988 |
Great Outdoors, TheThe Great Outdoors |
Kate Craig |
|
| 1989 |
Valmont |
Merteuil |
|
| 1990 |
Postcards from the Edge |
Evelyn Ames |
Cameo |
| The Grifters |
Myra Langtry |
London Film Critics' Circle Award for Newcomer of the Year
National Society of Film Critics Award for Best Supporting Actress
Nominated — Academy Award for Best Supporting Actress
Nominated — BAFTA Award for Best Actress in a Supporting Role |
| 1991 |
Guilty by Suspicion |
Ruth Merrill |
|
| Regarding Henry |
Sarah Turner |
|
| Bugsy |
Virginia Hill |
Nominated — Chicago Film Critics Association Award for Best Actress
Nominated — Golden Globe Award for Best Actress – Motion Picture Drama
Nominated — MTV Movie Award for Best Kiss |
| 1994 |
Love Affair |
Terry McKay |
|
| 1995 |
Richard III |
Queen Elizabeth |
|
| The American President |
Sydney Ellen Wade |
Nominated — American Comedy Award for Funniest Actress in a Motion Picture
Nominated — Golden Globe Award for Best Actress – Motion Picture Musical or Comedy |
| 1996 |
Mars Attacks! |
Barbara Land |
|
| 1998 |
The Siege |
Elise Kraft/Sharon Bridger |
Nominated — Blockbuster Entertainment Award for Favorite Actress - Suspense |
| 1999 |
In Dreams |
Claire Cooper |
|
| American Beauty |
Carolyn Burnham |
American Comedy Award for Funniest Actress in a Motion Picture
BAFTA Award for Best Actress in a Leading Role
London Film Critics Circle Award for Best Actress
Online Film Critics Society Award for Best Cast
San Diego Film Critics Society Award for Best Actress
Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role
Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture
Nominated — Academy Award for Best Actress
Nominated — Blockbuster Entertainment Award for Favorite Actress - Drama
Nominated — Chicago Film Critics Association Award for Best Actress
Nominated — Chlotrudis Award for Best Actress
Nominated — Golden Globe Award for Best Actress – Motion Picture Drama
Nominated — Las Vegas Film Critics Society Award for Best Actress
Nominated — Online Film Critics Society Award for Best Actress
Nominated — Satellite Award for Best Actress - Motion Picture Drama |
| 2000 |
What Planet Are You From? |
Susan Anderson |
|
| 2003 |
Open Range |
Sue Barlow |
- Bronze Wrangler for Outstanding Theatrical Motion Picture
- Nominated — Satellite Award for Best Supporting Actress – Motion Picture
|
| 2004 |
Being Julia |
Julia Lambert |
- Bangkok International Film Festival Award for Best Actress
- Golden Globe Award for Best Actress – Motion Picture Musical or Comedy
- National Board of Review Award for Best Actress
- Satellite Award for Best Actress – Motion Picture Musical or Comedy
- Southeastern Film Critics Association Award for Best Actress
- Nominated — Academy Award for Best Actress
- Nominated — Broadcast Film Critics Association Award for Best Actress
- Nominated — London Film Critics Circle Award for Actress of the Year
- Nominated — Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role
|
| 2005 |
Mrs. Harris |
Jean Harris |
- Nominated — Primetime Emmy Award for Outstanding Lead Actress – Miniseries or a Movie
- Nominated — Golden Globe Award for Best Actress – Miniseries or Television Film
- Nominated — Prism Award for Performance in a TV-Movie
- Nominated — Satellite Award for Best Actress – Miniseries or Television Film
- Nominated — Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Miniseries or Television Movie
|
| 2006 |
Running with Scissors |
Deirdre Burroughs |
- Nominated — Golden Globe Award for Best Actress – Motion Picture Musical or Comedy
- Nominated — Satellite Award for Best Actress – Motion Picture Musical or Comedy
- Nominated — St. Louis Gateway Film Critics Association Award for Best Actress
|
| 2008 |
Women, TheThe Women |
Sylvie Fowler |
|
| 2009 |
Mother and Child |
Karen |
Hollywood Film Festival Award for Best Actress (also for The Kids Are All Right) |
| 2010 |
Kids Are All Right, TheThe Kids Are All Right |
Nic |
- Golden Globe Award for Best Actress – Motion Picture Musical or Comedy
- Hollywood Film Festival Award for Best Actress (also for Mother and Child)
- Irish Film and Television Award for Best International Actress
- London Film Critics Circle Award for Actress of the Year
- New York Film Critics Circle Award for Best Actress
- Alliance of Women Film Journalists Award for Best Actress
- Women Film Critics Circle Award for Best Actress
- Women Film Critics Circle Award for Best Comedic Actress
- Nominated — Academy Award for Best Actress
- Nominated — BAFTA Award for Best Actress in a Leading Role
- Nominated — National Society of Film Critics Award for Best Actress
- Nominated — Boston Society of Film Critics Award for Best Actress
- Nominated — Broadcast Film Critics Association Award for Best Actress
- Nominated — Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role
- Nominated — Chicago Film Critics Association Award for Best Actress
- Nominated — Dallas-Fort Worth Film Critics Association Award for Best Actress
- Nominated — Houston Film Critics Society Award for Best Actress
- Nominated — Independent Spirit Award for Best Female Lead
- Nominated — Las Vegas Film Critics Society Award for Best Actress
- Nominated — Online Film Critics Society Award for Best Actress
- Nominated — Phoenix Film Critics Society Award for Best Actress
- Nominated — Satellite Award for Best Actress — Motion Picture Musical or Comedy
- Nominated — Vancouver Film Critics Circle Award for Best Actress
- Nominated — Washington D.C. Area Film Critics Association Award for Best Actress
|
| 2012 |
Ginger & Rosa |
May Bella |
|
| Imogene |
Zelda |
|
| Ruby Sparks |
Gertrude |
|
| 2013 |
Look of Love (film) |
Nikki |
post-production |