History
| Year | Event |
|---|---|
| 1824 | Charles Bell writes a report about ALS. |
| 1850 | English scientist Augustus Waller describes the appearance of shriveled nerve fibers |
| 1869 | French doctor Jean-Martin Charcot first describes ALS in scientific literature |
| 1881 | "Amyotrophic Lateral Sclerosis" is translated into English and published in a three-volume edition of Lectures on the Diseases of the Nervous System |
| 1939 | ALS becomes a cause célèbre in the United States when baseball legend Lou Gehrig's career—and, two years later, his life—is ended by the disease. He gives his farewell speech on 4 July 1939. |
| 1950s | ALS epidemic occurs among the Chamorro people on Guam |
| 1991 | Researchers link chromosome 21 to FALS (Familial ALS) |
| 1993 | SOD1 gene on chromosome 21 found to play a role in some cases of FALS |
| 1996 | Rilutek becomes the first FDA-approved drug for ALS |
| 1998 | The El Escorial criteria is developed as the standard for classifying ALS patient in clinical research |
| 1999 | The revised ALS Functional Rating Scale (ALSFRS-R) is published and soon becomes a gold standard measure for rating decline in ALS patient in clinical research |
| 2011 | Noncoding repeat expansions in C9ORF72 are found to be a major cause of ALS and frontotemporal dementia |
Read more about this topic: Amyotrophic Lateral Sclerosis
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—Ralph Waldo Emerson (1803–1882)
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—Sarah M. Grimke (1792–1873)