History
Year | Event |
---|---|
1824 | Charles Bell writes a report about ALS. |
1850 | English scientist Augustus Waller describes the appearance of shriveled nerve fibers |
1869 | French doctor Jean-Martin Charcot first describes ALS in scientific literature |
1881 | "Amyotrophic Lateral Sclerosis" is translated into English and published in a three-volume edition of Lectures on the Diseases of the Nervous System |
1939 | ALS becomes a cause célèbre in the United States when baseball legend Lou Gehrig's career—and, two years later, his life—is ended by the disease. He gives his farewell speech on 4 July 1939. |
1950s | ALS epidemic occurs among the Chamorro people on Guam |
1991 | Researchers link chromosome 21 to FALS (Familial ALS) |
1993 | SOD1 gene on chromosome 21 found to play a role in some cases of FALS |
1996 | Rilutek becomes the first FDA-approved drug for ALS |
1998 | The El Escorial criteria is developed as the standard for classifying ALS patient in clinical research |
1999 | The revised ALS Functional Rating Scale (ALSFRS-R) is published and soon becomes a gold standard measure for rating decline in ALS patient in clinical research |
2011 | Noncoding repeat expansions in C9ORF72 are found to be a major cause of ALS and frontotemporal dementia |
Read more about this topic: Amyotrophic Lateral Sclerosis
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—Henry David Thoreau (18171862)