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- Saco, Maine (SAO) (Amtrak station)
- Sacramento, California (SAC) (Sacramento Station)
- Sacramento, California State Capitol Drop Off Only (SCS) (Amtrak Thruway Motorcoach stop)
- Salem, Oregon (SLM) (Amtrak station)
- Salem, Oregon Greyhound Station (SLG)
- Salinas, California (SNS) (Amtrak station)
- Salisbury, Maryland (SLY)
- Salisbury, North Carolina (SAL) (Amtrak station)
- Salt Lake City, Utah (SLC) (Salt Lake City Intermodal Hub)
- San Antonio, Texas (SAS) (San Antonio Station)
- San Bernardino - Bus Stop, California (SBB)
- San Bernardino, California (SNB) (Amtrak station)
- San Clemente, California (SNP) (Amtrak station)
- San Diego, California (SAN) (Union Station)
- San Diego, California (OLT) (Old Town Transit Center)
- San Diego, California (SDZ) San Diego Zoo Bus Stop
- San Francisco, California Ferry Bldg (SFC) (Amtrak Thruway Motorcoach station)
- San Francisco, California Financial Ctr (SFF) (Amtrak Thruway Motorcoach station)
- San Francisco, California Fisherman's Wharf (SFW) (Amtrak Thruway Motorcoach station)
- San Francisco, California Moscone Convention Center (SFM) (Amtrak Thruway Motorcoach station)
- San Francisco, California Peninsula Line (SFP) San Francisco - Caltrain Station, California
- San Francisco, California Union Square (SFS) aka "Shopping Center" (Amtrak Thruway Motorcoach station)
- San Jose, California (SJC) (Diridon Station)
- San Juan Capistrano, California (SNC) (Amtrak station)
- San Luis Obispo, California (SLO) (Amtrak station)
- San Luis Obispo, California Cal Poly (SLP) bispo - Cal Poly Bus Stop, California
- San Marcos, Texas (SMC) (Amtrak station)
- San Pedro, California (SPD) (Amtrak station)
- San Pedro, California Bus Stop (SPO)
- Sanderson, Texas (SND) (Amtrak station) -Flag stop-
- Sandpoint, Idaho (SPT) (Amtrak station)
- Sandusky, Ohio (SKY) (Amtrak station)
- Sanford, Florida Auto Train Only (SFA) (Amtrak station)
- Sanford, Florida Regular Trains (SFD)
- Santa Ana, California (SNA) (Santa Ana Regional Transportation Center)
- Santa Barbara, California (SBA) (Amtrak station)
- Santa Clara, California - Santa Clara/Great America (GAC) Amtrak & ACE station
- Santa Clara, California - Santa Clara/University (SCC) Caltrain, Amtrak, and ACE station
- Santa Cruz, California (SCZ) Santa Cruz - Metro Center
- Santa Fe, New Mexico (SAF) (Amtrak station)
- Santa Maria, California (SAT) (Amtrak station)
- Santa Paula, California (SAP) (Amtrak station)
- Santa Rosa, California (SRC) (Amtrak station)
- Sarasota, Florida (SRA) (Amtrak station)
- Saratoga Springs, New York (SAR) (Amtrak station)
- Savannah, Georgia (SAV) (Amtrak station)
- Schenectady, New York (SDY) (Amtrak station)
- Schriever, Louisiana (SCH) (Amtrak station) -Flag stop-
- Scotts Valley, California (SVY) (Amtrak station)
- Seaford, Delaware (SAD) (Amtrak station)
- Searsport, Maine (SRT) (Amtrak station)
- Seaside, Oregon (SSD) Oregon Coachways
- Seattle, Washington (SEA) (King Street Station)
- Seattle, Washington Ferry Pier 69 (SVF)
- Sebring, Florida (SBG) (Amtrak station)
- Sedalia, Missouri (SED) (Amtrak station)
- Selma-Smithfield, North Carolina (SSM) (Union Station)
- Shelby, Montana (SBY) (Amtrak station)
- Shreveport, Louisiana (SHR)
- Simi Valley, California (SIM) (Amtrak station)
- Skykomish, Washington (SKW) (Amtrak station)
- Slidell, Louisiana (SDL) (Amtrak station)
- Socorro, New Mexico (SRO)
- Soda Springs, California (SOD) (Amtrak station)
- Solana Beach, California (SOL) (Amtrak station)
- Solvang, California (SLV) (Amtrak station)
- South Beloit, Illinois (BET)
- South Bend, Indiana (SOB) (Amtrak station)
- South Lake Tahoe, California (SLT) (Amtrak Thruway Motorcoach Stop)
- South Portsmouth, Kentucky (SPM)
- Southern Pines, North Carolina (SOP) (Amtrak station)
- Sparks, Nevada (SPR) Sparks - Rail Station, Nevada
- Sparks, Nevada Bus Station (SPX) Nugget Casino
- Spartanburg, South Carolina (SPB) (Amtrak station)
- Spokane, Washington (SPK) (Amtrak station)
- Springfield, Illinois (SPI) (C&A station)
- Springfield, Massachusetts (SPG) (Union Station)
- Squamish, British Columbia, Canada (SQA)
- St. Albans, Vermont (SAB) (Amtrak station)
- St. Catharines, Ontario, Canada (SCA) (Canadian railway station) used by the joint Via Rail/Amtrak Maple Leaf train
- St. Cloud, Minnesota (SCD) (Amtrak station)
- St. George, Utah (STG)
- St. Ignace, Michigan (STI)
- St. Joseph, Michigan (SJM) (Amtrak station)
- St. Lambert, Quebec Canada (SLQ) (VIA-AMT station)
- St. Louis, Missouri (STL) (Gateway Multimodal Transportation Center)
- St. Petersburg, Florida (STP) (Amtrak station)
- Stamford, Connecticut (STM) (Stamford Transportation Center)
- Stanley, North Dakota (STN) (Amtrak station)
- Staples, Minnesota (SPL)
- Stateline - Harvey's, California (SLH)
- Staunton, Virginia (STA) (Amtrak station)
- Stevens Pass, Washington (SSW)
- Stockton - ACE Station, California (SKT) ((Robert J. Cabral Station))
- Stockton, California (SKN) ((Stockton – San Joaquin Street Station))
- Sturtevant, Wisconsin (SVT)
- Suisun-Fairfield, California (SUI) (Amtrak station)
- Summit, Illinois (SMT)
- Sunriver, Oregon (SUN) Redmond Airport Shuttle
- Surrey, BC (SUY)
- Syracuse, New York (SYR) (William F. Walsh Regional Transportation Center)
- Syracuse, New York New York State Fair (NYF)
Read more about this topic: Amtrak Stations