Alternatives
In 1997, the National Cancer Institute published a set of recommendations called the Bethesda guidelines for the identification of individuals who should receive genetic testing for Lynch syndrome related tumors. The NCI revisited and revised these criteria in 2004.
The Revised Bethesda Guidelines are as follows:
- Colorectal carcinoma (CRC) diagnosed in a patient who is less than 50 years old;
- Presence of synchronous (at the same time) or metachronous (at another time i.e.- a re-occurrence of) CRC or other Lynch syndrome-associated tumors, regardless of age;
- CRC with high microsatellite instability histology diagnosed in a patient less than 60 years old;
- CRC diagnosed in one or more first-degree relatives with a Lynch syndrome-associated tumor, with one of the cancers being diagnosed at less than 50 years of age;
- CRC diagnosed in two or more first-degree or second-degree relatives with Lynch syndrome-associated tumors, regardless of age.
The Revised Bethesda Guidelines have been reported as being more accurate than the Amsterdam II Criteria in detecting individuals and families at risk of Lynch syndrome.
Read more about this topic: Amsterdam Criteria
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