Ammonium Metavanadate - Sensor

Sensor

Ammonium metavanadate has the ability to act as a sensor for N-Acetyltransferase activity in humans hepatocytes through the analysis of urine after the administration of isoniazide and ammonium metavanadate. N-Acetyltransferase is important because it acts as an important enzyme of drug metabolism. NH₄VO₃, forms a ligand complex with isoniazide and ligand formation happens at nitrogen and oxygen with V(V) as the metal. The interaction is dependent on the pH and the amount of AMV present. Higher acidity causes absorption intensity and the higher the concentration of complex formation. Lower pH decreases the content of VO2+ in solution and increases content of dioxohydroxovanadium(V) anion (VO₂OH) and hexadecaoxohexavanadate(V) anion (V₆O₁₆2-). This causes the complex formation to be more complete.