Cast
- Denzel Washington as Frank Lucas
- Russell Crowe as Det. Richie Roberts
- Ted Levine as Capt. Lou Toback
- Cuba Gooding Jr. as Nicky Barnes
- Josh Brolin as Det. Reno Trupo
- Clarence Williams III as Ellsworth "Bumpy" Johnson
- T.I. as Steve Lucas
- Carla Gugino as Laurie Roberts
- Common as Turner Lucas
- Idris Elba as Tango
- John Ortiz as Det. Javier Rivera
- Chiwetel Ejiofor as Huey Lucas
- Norman Reedus as Det. Norman Reilly
- Lymari Nadal as Eva Kendo Lucas
- Roger Guenveur Smith as Nate
- John Hawkes as Det. Freddie Spearman
- RZA as Det. Moses Jones
- Yul Vazquez as Det. Alfonso Abruzzo
- Malcolm Goodwin as Jimmy Zee
- Ruby Dee as Mama Lucas
- Ruben Santiago-Hudson as Doc
- Armand Assante as Dominic Cattano
- Jon Polito as Rossi
- Ric Young as Khun Sa
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