MC2
In the MC2 continuity, Reed Richards is badly scarred and he designs a small robot into which he claims to have transferred his brain when his body was damaged; in reality, Richards' injuries are minor, and he controls the robot remotely from an outpost in the Negative Zone. This robot, called Big Brain, is a member of the Fantastic Five, and is capable of projecting force fields and can hover or fly. When Reed solves the problem keeping Susan in stasis in the Negative Zone, the mental block preventing his scars from healing dissolves, and his appearance returns to normal.
In an alternate universe in the MC2 line where The Red Skull conquered the world and killed that worlds Captain America. Reed serves as an advisor for Doctor Doom who in this continuality killed Red Skull. After Doom and Crimson Curse fall into a portal Richards turns on fellow advisor Helmut Zemo. Later he becomes a mad scientist, aided by evil versions of Ben Grimm, Franklin Richards and Peter Parker. They are defeated by Spider Girl, Thunderstrike and Stinger.
When Dr. Doom returns, Reed is forced into a mental duel with the villain, which ends in a tie that banishes both their minds to the "Crossroads of Infinity". He is currently in Latveria, under the care of his wife.
Read more about this topic: Alternative Versions Of Mister Fantastic