Agatoxin - Toxicity

Toxicity

Alpha-agatoxin causes a rapid reversible paralysis in insects, while mu-agatoxin cause a slow long-lasting paralysis. When the two toxins will be injected at the same time, they are synergistic. So co-injection of these toxins leads to a paralysis for a very long, possible everlasting, period of time. Omega-agatoxin injection causes spasms leading to a progressive paralysis which will eventually lead to death in insects. Because insects have a much smaller repertoire of voltage-gated calcium channels and have a different pharmacology than vertebrates the effects can vary between species.

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