Agassi is a surname most prevalent among Iranians, and may refer to:
- Andre Agassi (born 1970), tennis player
- Emmanuel B. "Mike" Agassi (born 1930), Assyrian-Armenian boxer from Iran; father of Andre Agassi
- Joseph Agassi (born 1927), Israeli academic
- Shai Agassi (born 1968), Israeli Executive
- Carlos Agassi (born 1979), Iranian-Filipino rapper and model
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